HEBP2

Gene Information
  • Official Symbol: HEBP2
  • Official Name: heme binding protein 2
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 23593
  • UniProt: Q9Y5Z4
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016].
  • UniProt Summary: Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. {ECO:0000269|PubMed:17098234}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 18991
  • Expression level (log2 read counts): 2.61

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1