HECW1 [The Human Chemical-Genetic Interaction Map Project]

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======= HECW1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HECW1
  * **<color #00a2e8>Official Name</color>**: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23072|23072]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q76N89|Q76N89]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HECW1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HECW1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610384|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C2|
|WW|
|HECT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of sodium ion transmembrane transporter activity|
|negative regulation of sodium ion transmembrane transport|
|negative regulation of sodium ion transport|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|negative regulation of transporter activity|
|negative regulation of cation transmembrane transport|
|regulation of sodium ion transport|
|regulation of dendrite morphogenesis|
|negative regulation of ion transmembrane transport|
|negative regulation of transmembrane transport|
|negative regulation of ion transport|
|regulation of dendrite development|
|negative regulation of canonical Wnt signaling pathway|
|negative regulation of Wnt signaling pathway|
|positive regulation of protein catabolic process|
|ubiquitin protein ligase activity|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of transporter activity|
|regulation of canonical Wnt signaling pathway|
|protein polyubiquitination|
|regulation of cell morphogenesis involved in differentiation|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of cation transmembrane transport|
|proteasomal protein catabolic process|
|regulation of Wnt signaling pathway|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|positive regulation of catabolic process|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|regulation of transmembrane transport|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|protein catabolic process|
|protein ubiquitination|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|macromolecule catabolic process|
|regulation of anatomical structure morphogenesis|
|organonitrogen compound catabolic process|
|negative regulation of molecular function|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of cell communication|
|negative regulation of signaling|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.12|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.8|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.04|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|3.24|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4647
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HECW1 Expression in NALM6 Cells: 1.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>