HECW1

Gene Information

Official Symbol: HECW1
Official Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Aliases and Previous Symbols: N/A
Entrez ID: 23072
UniProt: Q76N89
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS. {ECO:0000269|PubMed:14684739}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.1μM R03 exp94	2.12
R-DABN 8μM R03 exp111	2.8
Rotenone 2μM R00 exp33	3.04
Nocodazole 0.2μM R02 exp64	3.24
DABN racemic mixture R03 exp93	3.72

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4647
Expression level (log2 read counts): 1.56

Expression Distribution

C2
WW
HECT

negative regulation of sodium ion transmembrane transporter activity
negative regulation of sodium ion transmembrane transport
negative regulation of sodium ion transport
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
negative regulation of cation transmembrane transport
regulation of sodium ion transport
regulation of dendrite morphogenesis
negative regulation of ion transmembrane transport
negative regulation of transmembrane transport
negative regulation of ion transport
regulation of dendrite development
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway
positive regulation of protein catabolic process
ubiquitin protein ligase activity
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
regulation of canonical Wnt signaling pathway
protein polyubiquitination
regulation of cell morphogenesis involved in differentiation
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of cation transmembrane transport
proteasomal protein catabolic process
regulation of Wnt signaling pathway
regulation of protein catabolic process
regulation of metal ion transport
positive regulation of catabolic process
regulation of ion transmembrane transport
negative regulation of transport
regulation of cell morphogenesis
regulation of neuron projection development
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
regulation of transmembrane transport
proteolysis involved in cellular protein catabolic process