HELT

Gene Information

Official Symbol: HELT
Official Name: helt bHLH transcription factor
Aliases and Previous Symbols: N/A
Entrez ID: 391723
UniProt: A6NFD8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9566
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
S-DABN 8μM R03 exp112	-1.86
Nicotinamide 2000μM R01 exp50	-1.81
Milciclib 2μM R08 exp502	1.75
Lead acetate 990μM R08 exp496	2.18

Hairy orange
HLH

GABAergic neuron differentiation in basal ganglia
suckling behavior
GABAergic neuron differentiation
multicellular organism aging
multi-organism behavior
multicellular organism growth
feeding behavior
post-embryonic development
transcription factor complex
anterior/posterior pattern specification
DNA-binding transcription repressor activity, RNA polymerase II-specific
aging
RNA polymerase II regulatory region sequence-specific DNA binding
regionalization
developmental growth
growth
pattern specification process
RNA polymerase II proximal promoter sequence-specific DNA binding
behavior
regulation of neurogenesis
negative regulation of transcription by RNA polymerase II
protein homodimerization activity
regulation of nervous system development
regulation of cell development
central nervous system development
neuron differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
neurogenesis