HELZ2

Entrez Summary: N/A
UniProt Summary: Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. {ECO:0000269|PubMed:16239304, ECO:0000269|PubMed:23525231}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ribonuclease activity
RNA helicase activity
nuclear receptor transcription coactivator activity
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
RNA phosphodiester bond hydrolysis
nuclear-transcribed mRNA catabolic process
mRNA catabolic process
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
regulation of lipid metabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
organic cyclic compound catabolic process
mRNA metabolic process
cellular macromolecule catabolic process
macromolecule catabolic process
positive regulation of transcription by RNA polymerase II
RNA binding
DNA binding
ATP binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
negative regulation of gene expression
positive regulation of RNA metabolic process
organic substance catabolic process
cellular catabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
membrane
positive regulation of biosynthetic process