HEPHL1

Entrez Summary: N/A
UniProt Summary: May function as a ferroxidase and may be involved in copper transport and homeostasis. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ONC212 0.15μM R08 exp513	-1.82
Heregulin-B 44ng/ml R08 exp486	-1.8
THZ531 0.11μM R07 exp409	-1.72
INK128 0.2μM R02 exp70	1.72
GSK343 3μM R03 exp124	1.94
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cu-oxidase 3
Cu-oxidase 2

ferroxidase activity
copper ion transport
copper ion binding
iron ion transport
iron ion homeostasis
oxidoreductase activity
transition metal ion transport
transition metal ion homeostasis
metal ion homeostasis
metal ion transport
cation homeostasis
inorganic ion homeostasis
ion homeostasis
cation transport
oxidation-reduction process
chemical homeostasis
ion transport
homeostatic process