HES5
Gene Information
- Official Symbol: HES5
- Official Name: hes family bHLH transcription factor 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 388585
- UniProt: Q5TA89
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Hairy orange |
| HLH |
GO Terms
| negative regulation of lymphoid progenitor cell differentiation |
| negative regulation of pro-B cell differentiation |
| negative regulation of forebrain neuron differentiation |
| negative regulation of inner ear auditory receptor cell differentiation |
| specification of loop of Henle identity |
| negative regulation of mechanoreceptor differentiation |
| negative regulation of inner ear receptor cell differentiation |
| proximal/distal pattern formation involved in nephron development |
| comma-shaped body morphogenesis |
| regulation of forebrain neuron differentiation |
| inhibition of neuroepithelial cell differentiation |
| specification of nephron tubule identity |
| regulation of pro-B cell differentiation |
| forebrain radial glial cell differentiation |
| S-shaped body morphogenesis |
| negative regulation of hematopoietic progenitor cell differentiation |
| regulation of mechanoreceptor differentiation |
| regulation of lymphoid progenitor cell differentiation |
| regulation of inner ear auditory receptor cell differentiation |
| metanephric nephron tubule morphogenesis |
| regulation of inner ear receptor cell differentiation |
| renal system pattern specification |
| pattern specification involved in kidney development |
| loop of Henle development |
| metanephric tubule morphogenesis |
| radial glial cell differentiation |
| negative regulation of astrocyte differentiation |
| negative regulation of oligodendrocyte differentiation |
| regulation of timing of cell differentiation |
| negative regulation of epidermal cell differentiation |
| glial cell fate commitment |
| regulation of development, heterochronic |
| metanephric nephron tubule development |
| segment specification |
| metanephric nephron epithelium development |
| nephron tubule formation |
| metanephric tubule development |
| negative regulation of epidermis development |
| metanephric nephron morphogenesis |
| axon ensheathment in central nervous system |
| central nervous system myelination |
| negative regulation of stem cell differentiation |
| metanephric epithelium development |
| neuronal stem cell population maintenance |
| negative regulation of glial cell differentiation |
| regulation of astrocyte differentiation |
| metanephros morphogenesis |
| inner ear receptor cell stereocilium organization |
| metanephric nephron development |
| proximal/distal pattern formation |
| establishment of epithelial cell polarity |
| positive regulation of BMP signaling pathway |
| regulation of oligodendrocyte differentiation |
| negative regulation of epithelial cell differentiation |
| negative regulation of gliogenesis |
| inner ear receptor cell development |
| oligodendrocyte development |
| regulation of myelination |
| positive regulation of Notch signaling pathway |
| inner ear receptor cell differentiation |
| astrocyte differentiation |
| mechanoreceptor differentiation |
| regulation of epidermal cell differentiation |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| forebrain generation of neurons |
| nephron morphogenesis |
| positive regulation of tyrosine phosphorylation of STAT protein |
| renal tubule morphogenesis |
| regulation of glial cell differentiation |
| oligodendrocyte differentiation |
| smoothened signaling pathway |
| nephron tubule development |
| regulation of tyrosine phosphorylation of STAT protein |
| renal tubule development |
| chondrocyte differentiation |
| metanephros development |
| kidney morphogenesis |
| positive regulation of receptor signaling pathway via JAK-STAT |
| regulation of epidermis development |
| positive regulation of smooth muscle cell proliferation |
| regulation of hematopoietic progenitor cell differentiation |
| regulation of BMP signaling pathway |
| positive regulation of receptor signaling pathway via STAT |
| segmentation |
| nephron epithelium development |
| regulation of Notch signaling pathway |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| myelination |
| glial cell development |
| ensheathment of neurons |
| axon ensheathment |
| regulation of gliogenesis |
| regulation of stem cell differentiation |
| establishment of cell polarity |
| embryonic epithelial tube formation |
| nephron development |
| Notch signaling pathway |
| regulation of embryonic development |
| kidney epithelium development |
| regulation of receptor signaling pathway via JAK-STAT |
| epithelial tube formation |
| regulation of smooth muscle cell proliferation |
| regulation of receptor signaling pathway via STAT |
| stem cell population maintenance |
| negative regulation of hemopoiesis |
| maintenance of cell number |
| regulation of epithelial cell differentiation |
| morphogenesis of embryonic epithelium |
| tube formation |
| cell maturation |
| protein dimerization activity |
| neural tube development |
| glial cell differentiation |
| cartilage development |
| positive regulation of peptidyl-tyrosine phosphorylation |
| inner ear development |
| establishment or maintenance of cell polarity |
| gliogenesis |
| anterior/posterior pattern specification |
| ear development |
| connective tissue development |
| negative regulation of neuron differentiation |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| developmental maturation |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| cell fate commitment |
| regulation of peptidyl-tyrosine phosphorylation |
| telencephalon development |
| kidney development |
| regulation of cellular response to growth factor stimulus |
| renal system development |
| negative regulation of neurogenesis |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| camera-type eye development |
| urogenital system development |
| regionalization |
| transcription factor binding |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| eye development |
| visual system development |
| sensory system development |
| forebrain development |
| chromatin binding |
| morphogenesis of an epithelium |
| pattern specification process |
| negative regulation of immune system process |
| cellular component |
| regulation of hemopoiesis |
| skeletal system development |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| negative regulation of cell differentiation |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| anatomical structure formation involved in morphogenesis |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| central nervous system development |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Trichostatin-A 0.06μM R07 exp415 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13221
- Expression level (log2 read counts): -7.68
Expression Distribution
HES5 Expression in NALM6 Cells: -7.68
