HESX1

Entrez Summary: This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency. [provided by RefSeq, Jul 2008].
UniProt Summary: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation. {ECO:0000250|UniProtKB:Q61658, ECO:0000269|PubMed:26781211}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

otic vesicle formation
otic vesicle morphogenesis
forebrain morphogenesis
otic vesicle development
nose development
brain morphogenesis
pituitary gland development
diencephalon development
inner ear morphogenesis
protein N-terminus binding
ear morphogenesis
endocrine system development
epithelial tube formation
tube formation
protein C-terminus binding
inner ear development
respiratory system development
ear development
DNA-binding transcription repressor activity, RNA polymerase II-specific
sensory organ morphogenesis
embryonic organ morphogenesis
epithelial tube morphogenesis
forebrain development
chromatin binding
gland development
morphogenesis of an epithelium
embryonic organ development
RNA polymerase II proximal promoter sequence-specific DNA binding
sensory organ development
tissue morphogenesis
embryonic morphogenesis
tube morphogenesis
brain development
head development
tube development
negative regulation of transcription by RNA polymerase II
anatomical structure formation involved in morphogenesis
animal organ morphogenesis
embryo development
central nervous system development