HHIP

Entrez Summary: This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011].
UniProt Summary: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. {ECO:0000269|PubMed:11472839, ECO:0000269|PubMed:19561609}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

hedgehog family protein binding
epithelial tube branching involved in lung morphogenesis
regulation of fibroblast growth factor receptor signaling pathway
negative regulation of smoothened signaling pathway
neuroblast proliferation
lung morphogenesis
catalytic activity
stem cell proliferation
ciliary membrane
neural precursor cell proliferation
regulation of smoothened signaling pathway
dorsal/ventral pattern formation
branching morphogenesis of an epithelial tube
morphogenesis of a branching epithelium
morphogenesis of a branching structure
lung development
respiratory tube development
respiratory system development
skeletal system morphogenesis
regulation of cellular response to growth factor stimulus
epithelial tube morphogenesis
regionalization
morphogenesis of an epithelium
pattern specification process
skeletal system development
cell population proliferation
tissue morphogenesis
cell surface
tube morphogenesis
zinc ion binding
tube development
negative regulation of apoptotic process
negative regulation of programmed cell death
animal organ morphogenesis
negative regulation of cell death
epithelium development
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
integral component of plasma membrane