HILPDA

Entrez Summary: N/A
UniProt Summary: Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation. {ECO:0000269|PubMed:15930302, ECO:0000269|PubMed:20624928}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Tunicamycin 0.04μM R07 exp418	-1.7
BAY-598 4μM R05 exp220	1.74

autocrine signaling
lipid droplet organization
positive regulation of lipid storage
regulation of lipid storage
positive regulation of lipid localization
lipid droplet
secretory granule
regulation of lipid localization
cellular response to hypoxia
cellular response to decreased oxygen levels
cellular response to oxygen levels
signaling receptor binding
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
positive regulation of cytokine production
cell surface
regulation of cytokine production
positive regulation of cell population proliferation
cell-cell signaling
response to abiotic stimulus
extracellular space
regulation of cell population proliferation
cellular response to stress
positive regulation of multicellular organismal process