HIP1R
Gene Information
- Official Symbol: HIP1R
- Official Name: huntingtin interacting protein 1 related
- Aliases and Previous Symbols: N/A
- Entrez ID: 9026
- UniProt: O75146
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.
Pfam Domains GO Terms
Pfam Domains
| ENTH |
| I LWEQ |
| ANTH |
GO Terms
| positive regulation of clathrin coat assembly |
| regulation of clathrin coat assembly |
| positive regulation of platelet-derived growth factor receptor-beta signaling pathway |
| positive regulation of platelet-derived growth factor receptor signaling pathway |
| negative regulation of Arp2/3 complex-mediated actin nucleation |
| regulation of platelet-derived growth factor receptor-beta signaling pathway |
| clathrin light chain binding |
| negative regulation of actin nucleation |
| clathrin adaptor activity |
| regulation of gastric acid secretion |
| AP-2 adaptor complex |
| regulation of Arp2/3 complex-mediated actin nucleation |
| actin cortical patch |
| regulation of clathrin-dependent endocytosis |
| clathrin coat assembly |
| regulation of platelet-derived growth factor receptor signaling pathway |
| synaptic membrane |
| regulation of actin nucleation |
| phosphatidylinositol-3,5-bisphosphate binding |
| phosphatidylinositol-3,4-bisphosphate binding |
| positive regulation of epidermal growth factor receptor signaling pathway |
| dendrite cytoplasm |
| positive regulation of ERBB signaling pathway |
| positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| clathrin binding |
| phosphatidylinositol-3,4,5-trisphosphate binding |
| regulation of digestive system process |
| regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| positive regulation of receptor-mediated endocytosis |
| negative regulation of actin filament polymerization |
| clathrin-coated vesicle |
| negative regulation of protein polymerization |
| regulation of mitochondrial membrane permeability |
| phosphatidylinositol-4,5-bisphosphate binding |
| regulation of membrane permeability |
| regulation of epidermal growth factor receptor signaling pathway |
| activation of cysteine-type endopeptidase activity involved in apoptotic process |
| phosphatidylinositol binding |
| regulation of ERBB signaling pathway |
| positive regulation of protein binding |
| ruffle membrane |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| positive regulation of mitochondrion organization |
| mitochondrial membrane organization |
| negative regulation of protein complex assembly |
| negative regulation of supramolecular fiber organization |
| SH3 domain binding |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cytoskeleton organization |
| digestive system development |
| dendritic spine |
| positive regulation of cysteine-type endopeptidase activity |
| regulation of actin filament polymerization |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| positive regulation of binding |
| protein stabilization |
| regulation of mitochondrion organization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of peptidase activity |
| actin filament binding |
| regulation of endocytosis |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitochondrial transport |
| regulation of protein binding |
| regulation of protein polymerization |
| receptor-mediated endocytosis |
| actin filament organization |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of protein complex assembly |
| postsynaptic density |
| regulation of actin filament organization |
| regulation of protein stability |
| apical plasma membrane |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| positive regulation of proteolysis |
| neuronal cell body |
| negative regulation of organelle organization |
| regulation of cellular component size |
| regulation of binding |
| regulation of actin filament-based process |
| regulation of apoptotic signaling pathway |
| regulation of endopeptidase activity |
| mitochondrion organization |
| regulation of peptidase activity |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| protein heterodimerization activity |
| actin cytoskeleton organization |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| regulation of vesicle-mediated transport |
| endocytosis |
| actin filament-based process |
| regulation of system process |
| positive regulation of organelle organization |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| import into cell |
| intracellular membrane-bounded organelle |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of proteolysis |
| positive regulation of hydrolase activity |
| regulation of secretion |
| cellular protein-containing complex assembly |
| membrane organization |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| regulation of cellular component biogenesis |
| positive regulation of transport |
| negative regulation of cell death |
| programmed cell death |
| identical protein binding |
| cell death |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| mitochondrion |
| regulation of hydrolase activity |
| regulation of organelle organization |
| positive regulation of catalytic activity |
| regulation of apoptotic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| protein-containing complex subunit organization |
| regulation of transport |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ixabepilone 0.004 to 0.005μM on day4 R04 exp184 | 1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4047
- Expression level (log2 read counts): 5.87
Expression Distribution
HIP1R Expression in NALM6 Cells: 5.87
