HIST3H2A

Entrez Summary: N/A
UniProt Summary: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

nuclear nucleosome
UV-damage excision repair
nucleosome disassembly
chromatin disassembly
protein-DNA complex disassembly
cellular response to UV
cellular response to light stimulus
response to UV
chromatin assembly or disassembly
nucleosome organization
cellular response to radiation
nuclear chromatin
protein-containing complex disassembly
protein-DNA complex subunit organization
response to light stimulus
cellular response to environmental stimulus
cellular response to abiotic stimulus
cellular component disassembly
response to radiation
protein heterodimerization activity
DNA repair
chromatin organization
DNA metabolic process
cellular response to DNA damage stimulus
chromosome organization
response to abiotic stimulus
DNA binding
cellular response to stress
protein-containing complex subunit organization