HKDC1

Entrez Summary: This gene encodes a member of the hexokinase protein family. The encoded protein is involved in glucose metabolism, and reduced expression may be associated with gestational diabetes mellitus. High expression of this gene may also be associated with poor prognosis in hepatocarcinoma. [provided by RefSeq, Sep 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Hexokinase 2
Hexokinase 1

mannokinase activity
fructokinase activity
glucokinase activity
glucose binding
glucose 6-phosphate metabolic process
carbohydrate phosphorylation
glycolytic process
ATP generation from ADP
ADP metabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
purine nucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
nucleoside diphosphate metabolic process
cellular glucose homeostasis
carbohydrate catabolic process
hexose metabolic process
cellular carbohydrate metabolic process
glucose homeostasis
carbohydrate homeostasis
monosaccharide metabolic process
ATP metabolic process
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
generation of precursor metabolites and energy
nucleotide metabolic process
nucleoside phosphate metabolic process
carbohydrate metabolic process
monocarboxylic acid metabolic process
nucleobase-containing small molecule metabolic process
cellular chemical homeostasis
organophosphate metabolic process
cellular homeostasis
carboxylic acid metabolic process
oxoacid metabolic process