HLA-DOA

Gene Information

Official Symbol: HLA-DOA
Official Name: major histocompatibility complex, class II, DO alpha
Aliases and Previous Symbols: N/A
Entrez ID: 3111
UniProt: P06340
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9795
Expression level (log2 read counts): 6.21

Expression Distribution

C1-set
MHC II alpha

negative regulation of antigen processing and presentation of peptide antigen via MHC class II
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
regulation of antigen processing and presentation of peptide antigen via MHC class II
negative regulation of antigen processing and presentation of peptide antigen
regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
regulation of antigen processing and presentation of peptide antigen
negative regulation of antigen processing and presentation
MHC class II receptor activity
MHC class II protein complex
MHC class II protein complex binding
regulation of antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
regulation of T cell differentiation
regulation of lymphocyte differentiation
antigen processing and presentation of exogenous peptide antigen
antigen processing and presentation of exogenous antigen
antigen processing and presentation of peptide antigen
endosome membrane
antigen processing and presentation
regulation of leukocyte differentiation
lysosomal membrane
regulation of T cell activation
negative regulation of immune system process
regulation of hemopoiesis
regulation of lymphocyte activation
regulation of leukocyte activation
adaptive immune response
regulation of cell activation
regulation of immune system process
regulation of cell differentiation
immune response