HLX [The Human Chemical-Genetic Interaction Map Project]

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======= HLX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HLX
  * **<color #00a2e8>Official Name</color>**: H2.0 like homeobox
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3142|3142]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14774|Q14774]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HLX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HLX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142995|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of T-helper 2 cell differentiation|
|positive regulation of T-helper 1 cell differentiation|
|regulation of T-helper 1 cell differentiation|
|regulation of T-helper 2 cell differentiation|
|enteric nervous system development|
|negative regulation of type 2 immune response|
|negative regulation of T-helper cell differentiation|
|embryonic digestive tract morphogenesis|
|positive regulation of T-helper 1 type immune response|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|positive regulation of T-helper cell differentiation|
|negative regulation of alpha-beta T cell differentiation|
|regulation of T-helper 1 type immune response|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|positive regulation of CD4-positive, alpha-beta T cell differentiation|
|regulation of type 2 immune response|
|positive regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|embryonic digestive tract development|
|negative regulation of alpha-beta T cell activation|
|negative regulation of T cell differentiation|
|autonomic nervous system development|
|positive regulation of alpha-beta T cell differentiation|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|digestive tract morphogenesis|
|positive regulation of organ growth|
|negative regulation of lymphocyte differentiation|
|positive regulation of alpha-beta T cell activation|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|positive regulation of T cell differentiation|
|regulation of alpha-beta T cell activation|
|positive regulation of lymphocyte differentiation|
|regulation of organ growth|
|negative regulation of leukocyte differentiation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|skeletal muscle tissue development|
|liver development|
|hepaticobiliary system development|
|digestive tract development|
|skeletal muscle organ development|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|digestive system development|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|positive regulation of developmental growth|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|positive regulation of hemopoiesis|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|positive regulation of leukocyte cell-cell adhesion|
|positive regulation of immune effector process|
|positive regulation of cell-cell adhesion|
|positive regulation of growth|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|regulation of leukocyte cell-cell adhesion|
|muscle tissue development|
|regulation of T cell activation|
|regulation of developmental growth|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|gland development|
|positive regulation of cell activation|
|sequence-specific DNA binding|
|embryonic organ development|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of immune effector process|
|muscle structure development|
|regulation of lymphocyte activation|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|regulation of cell activation|
|tube morphogenesis|
|regulation of growth|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|tube development|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18726
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HLX Expression in NALM6 Cells: 0.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>