HLX
Gene Information
- Official Symbol: HLX
- Official Name: H2.0 like homeobox
- Aliases and Previous Symbols: N/A
- Entrez ID: 3142
- UniProt: Q14774
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| negative regulation of T-helper 2 cell differentiation |
| positive regulation of T-helper 1 cell differentiation |
| regulation of T-helper 1 cell differentiation |
| regulation of T-helper 2 cell differentiation |
| enteric nervous system development |
| negative regulation of type 2 immune response |
| negative regulation of T-helper cell differentiation |
| embryonic digestive tract morphogenesis |
| positive regulation of T-helper 1 type immune response |
| negative regulation of CD4-positive, alpha-beta T cell differentiation |
| positive regulation of T-helper cell differentiation |
| negative regulation of alpha-beta T cell differentiation |
| regulation of T-helper 1 type immune response |
| negative regulation of CD4-positive, alpha-beta T cell activation |
| positive regulation of CD4-positive, alpha-beta T cell differentiation |
| regulation of type 2 immune response |
| positive regulation of CD4-positive, alpha-beta T cell activation |
| regulation of T-helper cell differentiation |
| embryonic digestive tract development |
| negative regulation of alpha-beta T cell activation |
| negative regulation of T cell differentiation |
| autonomic nervous system development |
| positive regulation of alpha-beta T cell differentiation |
| regulation of CD4-positive, alpha-beta T cell differentiation |
| digestive tract morphogenesis |
| positive regulation of organ growth |
| negative regulation of lymphocyte differentiation |
| positive regulation of alpha-beta T cell activation |
| regulation of CD4-positive, alpha-beta T cell activation |
| regulation of alpha-beta T cell differentiation |
| positive regulation of T cell differentiation |
| regulation of alpha-beta T cell activation |
| positive regulation of lymphocyte differentiation |
| regulation of organ growth |
| negative regulation of leukocyte differentiation |
| positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| positive regulation of adaptive immune response |
| negative regulation of T cell activation |
| negative regulation of immune effector process |
| negative regulation of leukocyte cell-cell adhesion |
| skeletal muscle tissue development |
| liver development |
| hepaticobiliary system development |
| digestive tract development |
| skeletal muscle organ development |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| digestive system development |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| negative regulation of lymphocyte activation |
| positive regulation of leukocyte differentiation |
| negative regulation of immune response |
| regulation of adaptive immune response |
| regulation of lymphocyte differentiation |
| positive regulation of developmental growth |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| positive regulation of hemopoiesis |
| negative regulation of cell activation |
| positive regulation of T cell activation |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| positive regulation of cell-cell adhesion |
| positive regulation of growth |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| muscle organ development |
| regulation of leukocyte cell-cell adhesion |
| muscle tissue development |
| regulation of T cell activation |
| regulation of developmental growth |
| positive regulation of lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| gland development |
| positive regulation of cell activation |
| sequence-specific DNA binding |
| embryonic organ development |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of immune effector process |
| muscle structure development |
| regulation of lymphocyte activation |
| embryonic morphogenesis |
| regulation of leukocyte activation |
| regulation of cell activation |
| tube morphogenesis |
| regulation of growth |
| regulation of cell adhesion |
| negative regulation of cell differentiation |
| tube development |
| positive regulation of immune response |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of developmental process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18726
- Expression level (log2 read counts): 0.52
Expression Distribution
HLX Expression in NALM6 Cells: 0.52
