HM13 [The Human Chemical-Genetic Interaction Map Project]

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======= HM13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HM13
  * **<color #00a2e8>Official Name</color>**: histocompatibility minor 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81502|81502]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TCT9|Q8TCT9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HM13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HM13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607106|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase A22B|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol|
|integral component of cytoplasmic side of endoplasmic reticulum membrane|
|aspartic endopeptidase activity, intramembrane cleaving|
|Derlin-1 retrotranslocation complex|
|signal peptide processing|
|retrograde protein transport, ER to cytosol|
|endoplasmic reticulum to cytosol transport|
|membrane protein intracellular domain proteolysis|
|membrane protein ectodomain proteolysis|
|protein exit from endoplasmic reticulum|
|integral component of lumenal side of endoplasmic reticulum membrane|
|membrane protein proteolysis|
|rough endoplasmic reticulum|
|peptidase activity|
|ERAD pathway|
|protein homotetramerization|
|protein tetramerization|
|protein processing|
|protein maturation|
|response to endoplasmic reticulum stress|
|ubiquitin protein ligase binding|
|protein homooligomerization|
|proteasomal protein catabolic process|
|in utero embryonic development|
|protein complex oligomerization|
|peptide metabolic process|
|proteolysis involved in cellular protein catabolic process|
|cell surface|
|cellular protein catabolic process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|protein catabolic process|
|cellular amide metabolic process|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|embryo development|
|intracellular protein transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.83|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HM13 Expression in NALM6 Cells: 6.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>