HM13

Entrez Summary: The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
integral component of cytoplasmic side of endoplasmic reticulum membrane
aspartic endopeptidase activity, intramembrane cleaving
Derlin-1 retrotranslocation complex
signal peptide processing
retrograde protein transport, ER to cytosol
endoplasmic reticulum to cytosol transport
membrane protein intracellular domain proteolysis
membrane protein ectodomain proteolysis
protein exit from endoplasmic reticulum
integral component of lumenal side of endoplasmic reticulum membrane
membrane protein proteolysis
rough endoplasmic reticulum
peptidase activity
ERAD pathway
protein homotetramerization
protein tetramerization
protein processing
protein maturation
response to endoplasmic reticulum stress
ubiquitin protein ligase binding
protein homooligomerization
proteasomal protein catabolic process
in utero embryonic development
protein complex oligomerization
peptide metabolic process
proteolysis involved in cellular protein catabolic process
cell surface
cellular protein catabolic process
chordate embryonic development
embryo development ending in birth or egg hatching
protein catabolic process
cellular amide metabolic process
protein homodimerization activity
cellular macromolecule catabolic process
endoplasmic reticulum membrane
embryo development
intracellular protein transport
response to organonitrogen compound
endoplasmic reticulum