HMBOX1 [The Human Chemical-Genetic Interaction Map Project]

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======= HMBOX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HMBOX1
  * **<color #00a2e8>Official Name</color>**: homeobox containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79618|79618]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NT76|Q6NT76]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HMBOX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HMBOX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor. {ECO:0000269|PubMed:16825764, ECO:0000269|PubMed:19757162}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|HNF-1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|double-stranded telomeric DNA binding|
|positive regulation of chromatin binding|
|regulation of chromatin binding|
|telomeric DNA binding|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|Cajal body|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|positive regulation of DNA biosynthetic process|
|regulation of telomere maintenance|
|PML body|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|positive regulation of chromosome organization|
|positive regulation of binding|
|positive regulation of DNA metabolic process|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|protein-containing complex binding|
|nuclear body|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|regulation of binding|
|sequence-specific DNA binding|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|negative regulation of transcription by RNA polymerase II|
|regulation of transferase activity|
|identical protein binding|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-2.23|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.89|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.71|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|1.71|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.8|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.85|
|[[:results:exp359|FK-506 30μM R07 exp359]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18305
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HMBOX1 Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>