HMBOX1

Gene Information

Official Symbol: HMBOX1
Official Name: homeobox containing 1
Aliases and Previous Symbols: N/A
Entrez ID: 79618
UniProt: Q6NT76
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor. {ECO:0000269|PubMed:16825764, ECO:0000269|PubMed:19757162}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol S 100μM R08 exp458	-2.23
PU-H71 1μM R08 exp515	-1.89
BI-D1870 2μM R04 exp162	-1.73
MK2206 4μM R08 exp504	-1.71
All-trans-Retinoic-Acid 8μM R07 exp333	1.71
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.8
VHL-ligand-1 20μM R07 exp421	1.85
FK-506 30μM R07 exp359	2.03

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18305
Expression level (log2 read counts): 5.45

Expression Distribution

Homeobox
HNF-1 N

double-stranded telomeric DNA binding
positive regulation of chromatin binding
regulation of chromatin binding
telomeric DNA binding
positive regulation of telomere maintenance via telomerase
positive regulation of telomerase activity
positive regulation of telomere maintenance via telomere lengthening
positive regulation of telomere maintenance
regulation of telomerase activity
Cajal body
regulation of telomere maintenance via telomerase
regulation of telomere maintenance via telomere lengthening
positive regulation of DNA biosynthetic process
regulation of telomere maintenance
PML body
nuclear chromosome, telomeric region
regulation of DNA biosynthetic process
positive regulation of chromosome organization
positive regulation of binding
positive regulation of DNA metabolic process
DNA-binding transcription repressor activity, RNA polymerase II-specific
protein-containing complex binding
nuclear body
regulation of chromosome organization
regulation of DNA metabolic process
regulation of binding
sequence-specific DNA binding
positive regulation of organelle organization
positive regulation of transferase activity
negative regulation of transcription by RNA polymerase II
regulation of transferase activity
identical protein binding
negative regulation of transcription, DNA-templated
positive regulation of cellular component organization
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
regulation of organelle organization
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
positive regulation of catalytic activity