HNF1A [The Human Chemical-Genetic Interaction Map Project]

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======= HNF1A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNF1A
  * **<color #00a2e8>Official Name</color>**: HNF1 homeobox A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6927|6927]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20823|P20823]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNF1A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNF1A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142410|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HNF-1B C|
|HNF-1A C|
|HNF-1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|renal glucose absorption|
|regulation of pronephros size|
|pronephros morphogenesis|
|regulation of kidney size|
|glucose import|
|pronephros development|
|natural killer cell differentiation|
|renal absorption|
|positive regulation of transcription initiation from RNA polymerase II promoter|
|positive regulation of DNA-templated transcription, initiation|
|regulation of transcription initiation from RNA polymerase II promoter|
|glucose transmembrane transport|
|hexose transmembrane transport|
|regulation of DNA-templated transcription, initiation|
|monosaccharide transmembrane transport|
|insulin secretion|
|carbohydrate transmembrane transport|
|natural killer cell activation|
|peptide hormone secretion|
|pancreas development|
|hormone secretion|
|carbohydrate transport|
|hormone transport|
|kidney morphogenesis|
|renal system process|
|liver development|
|hepaticobiliary system development|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein dimerization activity|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|glucose homeostasis|
|carbohydrate homeostasis|
|transcription regulatory region DNA binding|
|lymphocyte differentiation|
|kidney development|
|renal system development|
|urogenital system development|
|leukocyte differentiation|
|lymphocyte activation|
|gland development|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of anatomical structure size|
|regulation of hormone levels|
|hemopoiesis|
|protein-containing complex|
|hematopoietic or lymphoid organ development|
|immune system development|
|DNA-binding transcription factor activity|
|leukocyte activation|
|animal organ morphogenesis|
|secretion by cell|
|export from cell|
|cell activation|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of transcription by RNA polymerase II|
|transmembrane transport|
|DNA binding|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of RNA metabolic process|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.38|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.8|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3317
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNF1A Expression in NALM6 Cells: 2.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>