HNF1A

Entrez Summary: The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

renal glucose absorption
regulation of pronephros size
pronephros morphogenesis
regulation of kidney size
glucose import
pronephros development
natural killer cell differentiation
renal absorption
positive regulation of transcription initiation from RNA polymerase II promoter
positive regulation of DNA-templated transcription, initiation
regulation of transcription initiation from RNA polymerase II promoter
glucose transmembrane transport
hexose transmembrane transport
regulation of DNA-templated transcription, initiation
monosaccharide transmembrane transport
insulin secretion
carbohydrate transmembrane transport
natural killer cell activation
peptide hormone secretion
pancreas development
hormone secretion
carbohydrate transport
hormone transport
kidney morphogenesis
renal system process
liver development
hepaticobiliary system development
protein secretion
establishment of protein localization to extracellular region
protein dimerization activity
protein localization to extracellular region
signal release
peptide secretion
glucose homeostasis
carbohydrate homeostasis
transcription regulatory region DNA binding
lymphocyte differentiation
kidney development
renal system development
urogenital system development