HNF4A

Entrez Summary: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]. COMPLETENESS: complete on the 3' end.
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Hormone recep
zf-C4

ornithine metabolic process
phospholipid homeostasis
hepatocyte differentiation
type B pancreatic cell development
glandular epithelial cell development
type B pancreatic cell differentiation
enteroendocrine cell differentiation
signal transduction involved in regulation of gene expression
fatty acid binding
acylglycerol homeostasis
triglyceride homeostasis
regulation of gastrulation
endocrine pancreas development
glandular epithelial cell differentiation
columnar/cuboidal epithelial cell development
steroid hormone receptor activity
RNA polymerase II activating transcription factor binding
SMAD protein signal transduction
anion homeostasis
pancreas development
cholesterol homeostasis
sterol homeostasis
columnar/cuboidal epithelial cell differentiation
regulation of circadian rhythm
steroid hormone mediated signaling pathway
endocrine system development
liver development
hepaticobiliary system development
regulation of embryonic development
xenobiotic metabolic process
lipid homeostasis
response to glucose
response to hexose
response to monosaccharide
hormone-mediated signaling pathway
response to carbohydrate
transcription initiation from RNA polymerase II promoter
regulation of insulin secretion
negative regulation of cell growth
glucose homeostasis