HNRNPF [The Human Chemical-Genetic Interaction Map Project]

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======= HNRNPF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPF
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein F
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3185|3185]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52597|P52597]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601037|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RRM 1|
|zf-RNPHF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TBP-class protein binding|
|interleukin-12-mediated signaling pathway|
|single-stranded RNA binding|
|cellular response to interleukin-12|
|response to interleukin-12|
|fibroblast growth factor receptor signaling pathway|
|catalytic step 2 spliceosome|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|regulation of RNA splicing|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|cytokine-mediated signaling pathway|
|mRNA metabolic process|
|enzyme linked receptor protein signaling pathway|
|RNA processing|
|cellular response to cytokine stimulus|
|response to cytokine|
|cellular response to endogenous stimulus|
|RNA binding|
|response to endogenous stimulus|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.37|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.91|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.87|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.81|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.7|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.73|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.76|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.79|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.06|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.31|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.51|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.62|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.28|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPF Expression in NALM6 Cells: 8.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>