HNRNPF

Entrez Summary: N/A
UniProt Summary: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK591 2.6μM R03 exp128	-2.37
UM131593 0.2μM R03 exp106	-1.91
Nifuroxazide 5μM R03 exp102	-1.87
LLY-283 2.6μM R06 exp290	-1.81
MS023 2μM R03 exp134	-1.7
BVD-523 15μM R02 exp67	1.73
Vemurafenib 6.6μM R08 exp434	1.76
CB-839 10μM R05 exp224	1.79
I-BRD9 4μM R07 exp365	1.9
iCRT14 30μM R08 exp492	2.06
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	2.31
Rapamycin 10μM R00 exp30	2.51
Oligomycin-A 2μM R00 exp25	2.62
Hippuristanol 0.12μM R08 exp489 no dilution day6	3.28
Hippuristanol 0.12μM R08 exp488	3.55

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

RRM 1
zf-RNPHF

TBP-class protein binding
interleukin-12-mediated signaling pathway
single-stranded RNA binding
cellular response to interleukin-12
response to interleukin-12
fibroblast growth factor receptor signaling pathway
catalytic step 2 spliceosome
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of RNA splicing
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
cytokine-mediated signaling pathway
mRNA metabolic process
enzyme linked receptor protein signaling pathway
RNA processing
cellular response to cytokine stimulus
response to cytokine
cellular response to endogenous stimulus
RNA binding
response to endogenous stimulus
RNA metabolic process
membrane
gene expression