HNRNPH1 [The Human Chemical-Genetic Interaction Map Project]

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======= HNRNPH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HNRNPH1
  * **<color #00a2e8>Official Name</color>**: heterogeneous nuclear ribonucleoprotein H1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3187|3187]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31943|P31943]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HNRNPH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HNRNPH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-RNPHF|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|poly(U) RNA binding|
|fibroblast growth factor receptor signaling pathway|
|catalytic step 2 spliceosome|
|cellular response to fibroblast growth factor stimulus|
|response to fibroblast growth factor|
|regulation of RNA splicing|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|mRNA metabolic process|
|enzyme linked receptor protein signaling pathway|
|RNA processing|
|cellular response to endogenous stimulus|
|RNA binding|
|response to endogenous stimulus|
|RNA metabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.69|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.44|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.22|
|[[:results:exp433|LJH685 50μM R08 exp433]]|-2.1|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.99|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.95|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.84|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.8|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.7|
|[[:results:exp539|42°C R08 exp539]]|1.75|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.98|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.17|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.22|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.32|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.34|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.58|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.89|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|4.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 622/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|21/28|
|blood|25/28|
|bone|25/26|
|breast|28/33|
|central nervous system|52/56|
|cervix|3/4|
|colorectal|11/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|13/16|
|kidney|16/21|
|liver|15/20|
|lung|63/75|
|lymphocyte|15/16|
|ovary|23/26|
|pancreas|15/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|24/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1175
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HNRNPH1 Expression in NALM6 Cells: 10.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>