HNRNPH1

Entrez Summary: N/A
UniProt Summary: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-2.69
LLY-284 2.6μM R06 exp291	-2.44
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-2.22
LJH685 50μM R08 exp433	-2.1
BH1 1μM R04 exp169	-2
Fluvastatin 2.2μM R06 exp282	-1.99
BML-284 0.09μM R08 exp460	-1.95
Wortmannin 0.5μM R00 exp37	-1.84
GSK626616 14μM R08 exp485	-1.8
Mubritinib 0.2μM R01 exp48	-1.7
42°C R08 exp539	1.75
Dynasore 7μM R08 exp436	1.98
MLN-4924 0.2μM R00 exp21	2.17
3-Bromopyruvate 7μM R04 exp175	2.22
JQ1 0.8μM R08 exp435	2.32
Lead acetate 2000μM R08 exp497	2.34
Amiloride 100μM R08 exp447	2.58
Aminopterin 0.005μM R07 exp335	3.89
I-BRD9 4μM R07 exp365	4.46

Global Fraction of Cell Lines Where Essential: 622/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	21/28
blood	25/28
bone	25/26
breast	28/33
central nervous system	52/56
cervix	3/4
colorectal	11/17
esophagus	11/13
fibroblast	1/1
gastric	13/16
kidney	16/21
liver	15/20
lung	63/75
lymphocyte	15/16
ovary	23/26
pancreas	15/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	23/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	15/22
urinary tract	24/29
uterus	4/5

Expression Distribution

zf-RNPHF
RRM 1

poly(U) RNA binding
fibroblast growth factor receptor signaling pathway
catalytic step 2 spliceosome
cellular response to fibroblast growth factor stimulus
response to fibroblast growth factor
regulation of RNA splicing
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
mRNA processing
cellular response to growth factor stimulus
transmembrane receptor protein tyrosine kinase signaling pathway
response to growth factor
mRNA metabolic process
enzyme linked receptor protein signaling pathway
RNA processing
cellular response to endogenous stimulus
RNA binding
response to endogenous stimulus
RNA metabolic process
membrane
gene expression