HORMAD1

Entrez Summary: N/A
UniProt Summary: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of homologous chromosome segregation
meiotic recombination checkpoint
meiotic cell cycle checkpoint
meiotic DNA double-strand break formation
regulation of meiosis I
meiotic sister chromatid segregation
meiotic sister chromatid cohesion
meiosis II
meiosis II cell cycle process
negative regulation of meiotic nuclear division
negative regulation of meiotic cell cycle
synaptonemal complex assembly
synaptonemal complex organization
synaptonemal complex
regulation of meiotic nuclear division
synapsis
negative regulation of nuclear division
regulation of meiotic cell cycle
sister chromatid cohesion
negative regulation of reproductive process
homologous chromosome segregation
chromosome organization involved in meiotic cell cycle
oogenesis
meiotic chromosome segregation
blastocyst development
regulation of chromosome segregation
meiosis I
meiosis I cell cycle process
chromosome
female gamete generation
sister chromatid segregation
meiotic nuclear division
regulation of reproductive process
meiotic cell cycle process
regulation of nuclear division
cell cycle checkpoint
nuclear chromosome segregation
meiotic cell cycle
germ cell development
chromosome segregation