HOXA5 [The Human Chemical-Genetic Interaction Map Project]

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======= HOXA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXA5
  * **<color #00a2e8>Official Name</color>**: homeobox A5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3202|3202]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20719|P20719]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142952|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell-cell signaling involved in mammary gland development|
|bronchiole development|
|lung goblet cell differentiation|
|intestinal epithelial cell maturation|
|lobar bronchus epithelium development|
|trachea cartilage morphogenesis|
|lobar bronchus development|
|columnar/cuboidal epithelial cell maturation|
|trachea cartilage development|
|lung-associated mesenchyme development|
|mesenchymal-epithelial cell signaling|
|lung secretory cell differentiation|
|negative regulation of erythrocyte differentiation|
|bronchus development|
|intestinal epithelial cell development|
|trachea morphogenesis|
|respiratory system process|
|positive regulation of receptor biosynthetic process|
|epithelial cell maturation|
|mammary gland epithelial cell differentiation|
|regulation of mammary gland epithelial cell proliferation|
|mammary gland lobule development|
|mammary gland alveolus development|
|trachea development|
|lung epithelial cell differentiation|
|intestinal epithelial cell differentiation|
|lung cell differentiation|
|thyroid gland development|
|regulation of receptor biosynthetic process|
|epithelial tube branching involved in lung morphogenesis|
|cartilage morphogenesis|
|lung epithelium development|
|glandular epithelial cell differentiation|
|lung alveolus development|
|respiratory gaseous exchange by respiratory system|
|lung morphogenesis|
|regulation of erythrocyte differentiation|
|columnar/cuboidal epithelial cell development|
|mammary gland epithelium development|
|negative regulation of myeloid cell differentiation|
|multicellular organism growth|
|positive regulation of myeloid cell differentiation|
|embryonic skeletal system morphogenesis|
|columnar/cuboidal epithelial cell differentiation|
|RNA polymerase II distal enhancer sequence-specific DNA binding|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|negative regulation of vasculature development|
|endocrine system development|
|embryonic skeletal system development|
|mammary gland development|
|digestive tract development|
|branching morphogenesis of an epithelial tube|
|anatomical structure maturation|
|negative regulation of hemopoiesis|
|digestive system development|
|cell maturation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|cartilage development|
|respiratory tube development|
|positive regulation of hemopoiesis|
|epithelial cell development|
|respiratory system development|
|anterior/posterior pattern specification|
|mesenchyme development|
|connective tissue development|
|regulation of myeloid cell differentiation|
|skeletal system morphogenesis|
|developmental maturation|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|regulation of vasculature development|
|regionalization|
|regulation of epithelial cell proliferation|
|developmental growth|
|growth|
|gland development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|negative regulation of immune system process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|regulation of hemopoiesis|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|tube development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|positive regulation of cell differentiation|
|embryo development|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|cell-cell signaling|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|positive regulation of developmental process|
|DNA binding|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-2.06|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.91|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.19|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.26|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.75|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.99|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|3.21|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|3.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9832
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXA5 Expression in NALM6 Cells: -3.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>