HOXA5
Gene Information
- Official Symbol: HOXA5
- Official Name: homeobox A5
- Aliases and Previous Symbols: N/A
- Entrez ID: 3202
- UniProt: P20719
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
GO Terms
| cell-cell signaling involved in mammary gland development |
| bronchiole development |
| lung goblet cell differentiation |
| intestinal epithelial cell maturation |
| lobar bronchus epithelium development |
| trachea cartilage morphogenesis |
| lobar bronchus development |
| columnar/cuboidal epithelial cell maturation |
| trachea cartilage development |
| lung-associated mesenchyme development |
| mesenchymal-epithelial cell signaling |
| lung secretory cell differentiation |
| negative regulation of erythrocyte differentiation |
| bronchus development |
| intestinal epithelial cell development |
| trachea morphogenesis |
| respiratory system process |
| positive regulation of receptor biosynthetic process |
| epithelial cell maturation |
| mammary gland epithelial cell differentiation |
| regulation of mammary gland epithelial cell proliferation |
| mammary gland lobule development |
| mammary gland alveolus development |
| trachea development |
| lung epithelial cell differentiation |
| intestinal epithelial cell differentiation |
| lung cell differentiation |
| thyroid gland development |
| regulation of receptor biosynthetic process |
| epithelial tube branching involved in lung morphogenesis |
| cartilage morphogenesis |
| lung epithelium development |
| glandular epithelial cell differentiation |
| lung alveolus development |
| respiratory gaseous exchange by respiratory system |
| lung morphogenesis |
| regulation of erythrocyte differentiation |
| columnar/cuboidal epithelial cell development |
| mammary gland epithelium development |
| negative regulation of myeloid cell differentiation |
| multicellular organism growth |
| positive regulation of myeloid cell differentiation |
| embryonic skeletal system morphogenesis |
| columnar/cuboidal epithelial cell differentiation |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| negative regulation of vasculature development |
| endocrine system development |
| embryonic skeletal system development |
| mammary gland development |
| digestive tract development |
| branching morphogenesis of an epithelial tube |
| anatomical structure maturation |
| negative regulation of hemopoiesis |
| digestive system development |
| cell maturation |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| lung development |
| cartilage development |
| respiratory tube development |
| positive regulation of hemopoiesis |
| epithelial cell development |
| respiratory system development |
| anterior/posterior pattern specification |
| mesenchyme development |
| connective tissue development |
| regulation of myeloid cell differentiation |
| skeletal system morphogenesis |
| developmental maturation |
| regulation of angiogenesis |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| regulation of vasculature development |
| regionalization |
| regulation of epithelial cell proliferation |
| developmental growth |
| growth |
| gland development |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| negative regulation of immune system process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of hemopoiesis |
| skeletal system development |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| positive regulation of cell death |
| negative regulation of cell differentiation |
| tube development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| embryo development |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| epithelium development |
| cell-cell signaling |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| locomotion |
| positive regulation of developmental process |
| DNA binding |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9832
- Expression level (log2 read counts): -3.51
Expression Distribution
HOXA5 Expression in NALM6 Cells: -3.51
