HOXB13 [The Human Chemical-Genetic Interaction Map Project]

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======= HOXB13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HOXB13
  * **<color #00a2e8>Official Name</color>**: homeobox B13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10481|10481]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92826|Q92826]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HOXB13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HOXB13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604607|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|HoxA13 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|epithelial cell maturation involved in prostate gland development|
|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|
|prostate glandular acinus morphogenesis|
|branching involved in prostate gland morphogenesis|
|prostate glandular acinus development|
|epithelial cell differentiation involved in prostate gland development|
|epithelial cell maturation|
|prostate gland epithelium morphogenesis|
|prostate gland morphogenesis|
|methyl-CpG binding|
|response to testosterone|
|prostate gland development|
|gland morphogenesis|
|anatomical structure maturation|
|cell maturation|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|epithelial cell development|
|response to ketone|
|transcription factor complex|
|developmental maturation|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|angiogenesis|
|urogenital system development|
|blood vessel morphogenesis|
|gland development|
|epidermis development|
|sequence-specific DNA binding|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|tissue morphogenesis|
|response to wounding|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|epithelial cell differentiation|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cell development|
|negative regulation of gene expression|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5993
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HOXB13 Expression in NALM6 Cells: 2.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>