HOXB13

Entrez Summary: This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008].
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Homeobox
HoxA13 N

epithelial cell maturation involved in prostate gland development
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
prostate glandular acinus morphogenesis
branching involved in prostate gland morphogenesis
prostate glandular acinus development
epithelial cell differentiation involved in prostate gland development
epithelial cell maturation
prostate gland epithelium morphogenesis
prostate gland morphogenesis
methyl-CpG binding
response to testosterone
prostate gland development
gland morphogenesis
anatomical structure maturation
cell maturation
morphogenesis of a branching epithelium
morphogenesis of a branching structure
epithelial cell development
response to ketone
transcription factor complex
developmental maturation
DNA-binding transcription repressor activity, RNA polymerase II-specific
angiogenesis
urogenital system development
blood vessel morphogenesis
gland development
epidermis development
sequence-specific DNA binding
reproductive structure development
reproductive system development
morphogenesis of an epithelium
blood vessel development
vasculature development
cardiovascular system development
tissue morphogenesis
response to wounding
tube morphogenesis
developmental process involved in reproduction
regulation of growth
epithelial cell differentiation