HOXB8

Entrez Summary: N/A
UniProt Summary: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

grooming behavior
dorsal spinal cord development
sensory perception of pain
negative regulation of myeloid cell differentiation
adult locomotory behavior
embryonic skeletal system morphogenesis
spinal cord development
embryonic skeletal system development
negative regulation of hemopoiesis
adult behavior
locomotory behavior
anterior/posterior pattern specification
regulation of myeloid cell differentiation
skeletal system morphogenesis
embryonic organ morphogenesis
regionalization
sequence-specific DNA binding
embryonic organ development
pattern specification process
negative regulation of immune system process
regulation of hemopoiesis
skeletal system development
embryonic morphogenesis
behavior
chordate embryonic development
embryo development ending in birth or egg hatching
negative regulation of cell differentiation
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process
animal organ morphogenesis
sensory perception
embryo development
central nervous system development
negative regulation of transcription, DNA-templated
negative regulation of multicellular organismal process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
nervous system process
negative regulation of cellular macromolecule biosynthetic process