HPX [The Human Chemical-Genetic Interaction Map Project]

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======= HPX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HPX
  * **<color #00a2e8>Official Name</color>**: hemopexin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3263|3263]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02790|P02790]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HPX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HPX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/142290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hemopexin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of humoral immune response mediated by circulating immunoglobulin|
|positive regulation of interferon-gamma-mediated signaling pathway|
|positive regulation of response to interferon-gamma|
|heme transporter activity|
|heme transport|
|hemoglobin metabolic process|
|regulation of humoral immune response mediated by circulating immunoglobulin|
|iron coordination entity transport|
|endocytic vesicle lumen|
|positive regulation of humoral immune response|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to interferon-gamma|
|heme metabolic process|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|porphyrin-containing compound metabolic process|
|positive regulation of immunoglobulin production|
|cofactor transport|
|positive regulation of cytokine-mediated signaling pathway|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|positive regulation of response to cytokine stimulus|
|tetrapyrrole metabolic process|
|cellular iron ion homeostasis|
|pigment metabolic process|
|regulation of immunoglobulin production|
|positive regulation of tyrosine phosphorylation of STAT protein|
|iron ion transport|
|regulation of tyrosine phosphorylation of STAT protein|
|iron ion homeostasis|
|positive regulation of receptor signaling pathway via JAK-STAT|
|positive regulation of receptor signaling pathway via STAT|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|positive regulation of lymphocyte mediated immunity|
|cellular transition metal ion homeostasis|
|transition metal ion transport|
|regulation of receptor signaling pathway via JAK-STAT|
|transition metal ion homeostasis|
|positive regulation of leukocyte mediated immunity|
|regulation of receptor signaling pathway via STAT|
|regulation of humoral immune response|
|regulation of production of molecular mediator of immune response|
|blood microparticle|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|regulation of adaptive immune response|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of peptidyl-tyrosine phosphorylation|
|regulation of leukocyte mediated immunity|
|positive regulation of immune effector process|
|receptor-mediated endocytosis|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|cofactor metabolic process|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|endocytosis|
|cellular metal ion homeostasis|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|import into cell|
|viral process|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of defense response|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|cation transport|
|positive regulation of immune response|
|cellular homeostasis|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|ion transport|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|nitrogen compound transport|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8144
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HPX Expression in NALM6 Cells: -1.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>