HPX

Gene Information

Official Symbol: HPX
Official Name: hemopexin
Aliases and Previous Symbols: N/A
Entrez ID: 3263
UniProt: P02790
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8144
Expression level (log2 read counts): -1.79

Expression Distribution

positive regulation of humoral immune response mediated by circulating immunoglobulin
positive regulation of interferon-gamma-mediated signaling pathway
positive regulation of response to interferon-gamma
heme transporter activity
heme transport
hemoglobin metabolic process
regulation of humoral immune response mediated by circulating immunoglobulin
iron coordination entity transport
endocytic vesicle lumen
positive regulation of humoral immune response
regulation of interferon-gamma-mediated signaling pathway
regulation of response to interferon-gamma
heme metabolic process
positive regulation of immunoglobulin mediated immune response
positive regulation of B cell mediated immunity
porphyrin-containing compound metabolic process
positive regulation of immunoglobulin production
cofactor transport
positive regulation of cytokine-mediated signaling pathway
regulation of immunoglobulin mediated immune response
regulation of B cell mediated immunity
positive regulation of response to cytokine stimulus
tetrapyrrole metabolic process
cellular iron ion homeostasis
pigment metabolic process
regulation of immunoglobulin production
positive regulation of tyrosine phosphorylation of STAT protein
iron ion transport
regulation of tyrosine phosphorylation of STAT protein
iron ion homeostasis
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
positive regulation of production of molecular mediator of immune response
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
positive regulation of adaptive immune response
positive regulation of lymphocyte mediated immunity
cellular transition metal ion homeostasis
transition metal ion transport
regulation of receptor signaling pathway via JAK-STAT
transition metal ion homeostasis