HRASLS

Entrez Summary: N/A
UniProt Summary: Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activities, transferring an acyl group of PCs to the amino group of PEs and the hydroxyl group of lyso PCs. {ECO:0000269|PubMed:21880860}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-acyl-2-lysophosphatidylserine acylhydrolase activity
N-acylphosphatidylethanolamine metabolic process
phosphatidylserine 1-acylhydrolase activity
O-acyltransferase activity
N-acyltransferase activity
nuclear envelope lumen
phospholipase A1 activity
phosphatidylethanolamine metabolic process
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity
phosphatidylcholine metabolic process
ammonium ion metabolic process
lipid catabolic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
cellular amide metabolic process
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
organic substance catabolic process