HRASLS2

Entrez Summary: N/A
UniProt Summary: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC. {ECO:0000269|PubMed:19615464}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
SGC2043 10μM R03 exp152	1.78
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.86

1-acyl-2-lysophosphatidylserine acylhydrolase activity
N-acylphosphatidylethanolamine metabolic process
phosphatidylserine 1-acylhydrolase activity
N-acyltransferase activity
phospholipase A1 activity
phosphatidylethanolamine metabolic process
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phosphatidylethanolamine acyl-chain remodeling
phospholipase A2 activity
phosphatidylcholine metabolic process
ammonium ion metabolic process
lipid catabolic process
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
cellular amide metabolic process
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
organic substance catabolic process