HRASLS5

Entrez Summary: N/A
UniProt Summary: catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, including the endocannabinoid anandamide. {ECO:0000269|PubMed:19000777}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

1-acyl-2-lysophosphatidylserine acylhydrolase activity
N-acylphosphatidylethanolamine metabolic process
phosphatidylserine 1-acylhydrolase activity
N-acyltransferase activity
phospholipase A1 activity
phosphatidylethanolamine metabolic process
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
cellular amide metabolic process
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process