HRH4

Gene Information

Official Symbol: HRH4
Official Name: histamine receptor H4
Aliases and Previous Symbols: N/A
Entrez ID: 59340
UniProt: Q9H3N8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist). {ECO:0000269|PubMed:12503632}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18836
Expression level (log2 read counts): 1.36

Expression Distribution

7tm 1
7TM GPCR Srsx

histamine receptor activity
G protein-coupled acetylcholine receptor activity
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway
G protein-coupled acetylcholine receptor signaling pathway
acetylcholine receptor signaling pathway
response to acetylcholine
cellular response to acetylcholine
G protein-coupled serotonin receptor activity
G protein-coupled serotonin receptor signaling pathway
neurotransmitter receptor activity
postsynaptic signal transduction
serotonin receptor signaling pathway
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
cellular response to dopamine
response to dopamine
signal transduction involved in cellular response to ammonium ion
cellular response to catecholamine stimulus
cellular response to monoamine stimulus
response to catecholamine
response to monoamine
cellular response to ammonium ion
response to ammonium ion
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
cellular response to drug
dendrite
chemical synaptic transmission
anterograde trans-synaptic signaling
cellular calcium ion homeostasis
trans-synaptic signaling
calcium ion homeostasis
synaptic signaling
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
inflammatory response
cellular response to organic cyclic compound
cellular metal ion homeostasis
cellular response to organonitrogen compound