HRNR

Entrez Summary: N/A
UniProt Summary: Component of the epidermal cornified cell envelopes. {ECO:0000269|PubMed:21282207}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell envelope organization
external encapsulating structure organization
keratohyalin granule
structural constituent of epidermis
transition metal ion binding
establishment of skin barrier
regulation of water loss via skin
cornified envelope
multicellular organismal water homeostasis
water homeostasis
azurophil granule lumen
keratinization
keratinocyte differentiation
epidermal cell differentiation
multicellular organismal homeostasis
collagen-containing extracellular matrix
skin development
epidermis development
neutrophil degranulation
neutrophil activation involved in immune response
regulation of body fluid levels
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
epithelial cell differentiation
perinuclear region of cytoplasm
regulated exocytosis
calcium ion binding
leukocyte mediated immunity
exocytosis
leukocyte activation
secretion by cell
export from cell
cell activation