HRSP12 [The Human Chemical-Genetic Interaction Map Project]

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======= HRSP12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIDA
  * **<color #00a2e8>Official Name</color>**: reactive intermediate imine deaminase A homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10247|10247]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52758|P52758]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HRSP12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HRSP12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602487|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. {ECO:0000269|PubMed:20817725, ECO:0000269|PubMed:22094463}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ribonuc L-PSP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|deaminase activity|
|endoribonuclease activity, producing 3-phosphomonoesters|
|L-threonine catabolic process to glycine|
|threonine catabolic process|
|long-chain fatty acid binding|
|threonine metabolic process|
|G1 to G0 transition|
|glycine metabolic process|
|transition metal ion binding|
|response to salt|
|aspartate family amino acid catabolic process|
|mRNA destabilization|
|RNA destabilization|
|serine family amino acid metabolic process|
|positive regulation of mRNA catabolic process|
|aspartate family amino acid metabolic process|
|positive regulation of mRNA metabolic process|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|neurotransmitter metabolic process|
|alpha-amino acid catabolic process|
|peroxisome|
|negative regulation of epithelial cell proliferation|
|cellular amino acid catabolic process|
|negative regulation of translation|
|drug catabolic process|
|negative regulation of cellular amide metabolic process|
|RNA phosphodiester bond hydrolysis|
|mRNA binding|
|lung development|
|respiratory tube development|
|regulation of mRNA stability|
|regulation of RNA stability|
|respiratory system development|
|regulation of mRNA catabolic process|
|alpha-amino acid metabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|kidney development|
|renal system development|
|nucleic acid phosphodiester bond hydrolysis|
|cellular amino acid metabolic process|
|urogenital system development|
|regulation of mRNA metabolic process|
|regulation of epithelial cell proliferation|
|regulation of translation|
|regulation of neurotransmitter levels|
|positive regulation of cellular catabolic process|
|mitochondrial matrix|
|nucleobase-containing compound catabolic process|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|small molecule catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|posttranscriptional regulation of gene expression|
|negative regulation of cell population proliferation|
|mRNA metabolic process|
|brain development|
|head development|
|regulation of cellular catabolic process|
|tube development|
|response to lipid|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|carboxylic acid metabolic process|
|central nervous system development|
|regulation of catabolic process|
|cell cycle process|
|oxoacid metabolic process|
|organic acid metabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|mitochondrion|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of cell population proliferation|
|RNA metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.423|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10228
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HRSP12 Expression in NALM6 Cells: 3.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>