HRSP12

Entrez Summary: N/A
UniProt Summary: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. {ECO:0000269|PubMed:20817725, ECO:0000269|PubMed:22094463}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

deaminase activity
endoribonuclease activity, producing 3-phosphomonoesters
L-threonine catabolic process to glycine
threonine catabolic process
long-chain fatty acid binding
threonine metabolic process
G1 to G0 transition
glycine metabolic process
transition metal ion binding
response to salt
aspartate family amino acid catabolic process
mRNA destabilization
RNA destabilization
serine family amino acid metabolic process
positive regulation of mRNA catabolic process
aspartate family amino acid metabolic process
positive regulation of mRNA metabolic process
RNA phosphodiester bond hydrolysis, endonucleolytic
neurotransmitter metabolic process
alpha-amino acid catabolic process
peroxisome
negative regulation of epithelial cell proliferation
cellular amino acid catabolic process
negative regulation of translation
drug catabolic process
negative regulation of cellular amide metabolic process
RNA phosphodiester bond hydrolysis
mRNA binding
lung development
respiratory tube development
regulation of mRNA stability
regulation of RNA stability
respiratory system development
regulation of mRNA catabolic process
alpha-amino acid metabolic process
mRNA catabolic process
RNA catabolic process
organic acid catabolic process
carboxylic acid catabolic process
kidney development