HS2ST1

Entrez Summary: N/A
UniProt Summary: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

heparan sulfate 2-O-sulfotransferase activity
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
heparan sulfate proteoglycan biosynthetic process
sulfotransferase activity
heparan sulfate proteoglycan metabolic process
cellular polysaccharide biosynthetic process
polysaccharide biosynthetic process
cellular carbohydrate biosynthetic process
proteoglycan biosynthetic process
cellular polysaccharide metabolic process
polysaccharide metabolic process
proteoglycan metabolic process
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
carbohydrate biosynthetic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
cellular carbohydrate metabolic process
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
carbohydrate derivative biosynthetic process
Golgi membrane
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
membrane