HS3ST6

Gene Information
  • Official Symbol: HS3ST6
  • Official Name: heparan sulfate-glucosamine 3-sulfotransferase 6
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 64711
  • UniProt: Q96QI5
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3- OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. {ECO:0000269|PubMed:15303968}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 9605
  • Expression level (log2 read counts): -6.6

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1