HSCB [The Human Chemical-Genetic Interaction Map Project]

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======= HSCB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: HSCB
  * **<color #00a2e8>Official Name</color>**: HscB mitochondrial iron-sulfur cluster cochaperone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=150274|150274]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWL3|Q8IWL3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=HSCB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20HSCB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608142|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. {ECO:0000269|PubMed:20668094}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DnaJ|
|HSCB C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|[2Fe-2S] cluster assembly|
|protein maturation by iron-sulfur cluster transfer|
|iron-sulfur cluster assembly|
|metallo-sulfur cluster assembly|
|ATPase activator activity|
|positive regulation of ATPase activity|
|regulation of ATPase activity|
|chaperone binding|
|cofactor biosynthetic process|
|protein maturation|
|sulfur compound metabolic process|
|cofactor metabolic process|
|protein complex oligomerization|
|molecular function|
|positive regulation of hydrolase activity|
|identical protein binding|
|mitochondrion|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein-containing complex assembly|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.03|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.8|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.7|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.71|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.72|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fdxr|FDXR]]|0.467|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 78/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|4/26|
|breast|4/33|
|central nervous system|13/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|3/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|6/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 141
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='HSCB Expression in NALM6 Cells: 3.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>