HSCB

Entrez Summary: N/A
UniProt Summary: Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria. {ECO:0000269|PubMed:20668094}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 78/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	4/26
breast	4/33
central nervous system	13/56
cervix	1/4
colorectal	1/17
esophagus	1/13
fibroblast	1/1
gastric	2/16
kidney	3/21
liver	0/20
lung	5/75
lymphocyte	3/16
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	2/22
urinary tract	6/29
uterus	0/5

Expression Distribution

DnaJ
HSCB C

[2Fe-2S] cluster assembly
protein maturation by iron-sulfur cluster transfer
iron-sulfur cluster assembly
metallo-sulfur cluster assembly
ATPase activator activity
positive regulation of ATPase activity
regulation of ATPase activity
chaperone binding
cofactor biosynthetic process
protein maturation
sulfur compound metabolic process
cofactor metabolic process
protein complex oligomerization
molecular function
positive regulation of hydrolase activity
identical protein binding
mitochondrion
regulation of hydrolase activity
positive regulation of catalytic activity
protein-containing complex assembly
positive regulation of molecular function
protein-containing complex subunit organization
gene expression