HSD11B2

Entrez Summary: There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
regulation of blood volume by renal aldosterone
glucocorticoid biosynthetic process
positive regulation of systemic arterial blood pressure
renal system process involved in regulation of blood volume
glucocorticoid metabolic process
response to food
renal system process involved in regulation of systemic arterial blood pressure
steroid binding
positive regulation of blood pressure
regulation of systemic arterial blood pressure by hormone
NAD binding
steroid hormone biosynthetic process
regulation of systemic arterial blood pressure mediated by a chemical signal
endocrine process
hormone biosynthetic process
regulation of systemic arterial blood pressure
renal system process
steroid biosynthetic process
response to glucocorticoid
response to corticosteroid
female pregnancy
regulation of blood pressure
hormone metabolic process
multi-multicellular organism process
response to insulin
steroid metabolic process
response to steroid hormone
response to hypoxia
response to decreased oxygen levels
response to oxygen levels
blood circulation
response to peptide hormone
circulatory system process
response to peptide
regulation of body fluid levels
response to nutrient levels
response to extracellular stimulus
regulation of hormone levels
lipid biosynthetic process