HSD17B2

Entrez Summary: N/A
UniProt Summary: Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
testosterone dehydrogenase (NAD+) activity
estradiol 17-beta-dehydrogenase activity
estrogen biosynthetic process
estrogen metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
response to retinoic acid
cellular hormone metabolic process
steroid biosynthetic process
placenta development
hormone metabolic process
steroid metabolic process
response to acid chemical
in utero embryonic development
reproductive structure development
reproductive system development
regulation of hormone levels
lipid biosynthetic process
chordate embryonic development
embryo development ending in birth or egg hatching
developmental process involved in reproduction
response to lipid
endoplasmic reticulum membrane
oxidation-reduction process
embryo development
lipid metabolic process
organic cyclic compound biosynthetic process
reproductive process
reproduction
response to oxygen-containing compound