HSD17B6

Entrez Summary: N/A
UniProt Summary: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. {ECO:0000269|PubMed:10896656, ECO:0000269|PubMed:11360992, ECO:0000269|PubMed:11513953}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

testosterone dehydrogenase (NAD+) activity
androgen catabolic process
androgen biosynthetic process
estradiol 17-beta-dehydrogenase activity
hormone catabolic process
retinol dehydrogenase activity
androgen metabolic process
steroid catabolic process
steroid hormone biosynthetic process
catalytic activity
hormone biosynthetic process
electron transfer activity
oxidoreductase activity
cellular hormone metabolic process
steroid biosynthetic process
early endosome membrane
electron transport chain
hormone metabolic process
steroid metabolic process
lipid catabolic process
generation of precursor metabolites and energy
organic cyclic compound catabolic process
regulation of hormone levels
lipid biosynthetic process
oxidation-reduction process
endoplasmic reticulum
lipid metabolic process
organic cyclic compound biosynthetic process
organic substance catabolic process