HSPB6

Entrez Summary: This locus encodes a heat shock protein. The encoded protein likely plays a role in smooth muscle relaxation. [provided by RefSeq, Jan 2012].
UniProt Summary: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity. {ECO:0000269|PubMed:14717697, ECO:0000269|PubMed:19845507, ECO:0000269|PubMed:20843828, ECO:0000269|PubMed:22427880, ECO:0000305, ECO:0000305|PubMed:22794279}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Crystallin
HSP20

negative regulation of cardiac muscle cell apoptotic process
structural constituent of eye lens
negative regulation of striated muscle cell apoptotic process
negative regulation of muscle cell apoptotic process
regulation of cardiac muscle cell apoptotic process
regulation of striated muscle cell apoptotic process
chaperone-mediated protein folding
regulation of muscle cell apoptotic process
chaperone binding
unfolded protein binding
regulation of muscle contraction
positive regulation of angiogenesis
positive regulation of vasculature development
protein folding
regulation of muscle system process
regulation of angiogenesis
regulation of vasculature development
regulation of system process
protein homodimerization activity
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
regulation of anatomical structure morphogenesis
positive regulation of developmental process
regulation of apoptotic process
regulation of programmed cell death
regulation of cell death
positive regulation of multicellular organismal process
extracellular region